I came across an argument on the internet that a trans-woman is mentally ill, because she is ignoring a biological fact namely that you need a y chromosome to be a man.
Compare the following argument: a woman without ovaries who adopts a child and considers herself a mother is mentally ill because she is ignoring the biological fact – you need ovaries to become a mother.
“Man” like “mother” is a cultural, legal, emotional and perhaps aesthetic categories and it is a mistake to read our culture, law, emotions and aesthetics directly from biology. Biology may give us some problems but it is up to us to solve them.
Aristotle thought it was fine; but he believed some people were naturally slaves too.